Preclinical Evaluation of a Lead Specific Chelator (PSC) Conjugated to Radiopeptides for ²⁰³Pb and ²¹²Pb-Based Theranostics

²⁰³Pb and ²¹²Pb have emerged as promising theranostic isotopes for image-guided α-particle radionuclide therapy for cancers. Here, we report a cyclen-based Pb specific chelator (PSC) that is conjugated to tyr³-octreotide via a PEG₂ linker (PSC-PEG-T) targe...

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Autori principali:	Mengshi Li, Nicholas J. Baumhover, Dijie Liu, Brianna S. Cagle, Frédéric Boschetti, Guillaume Paulin, Dongyoul Lee, Zhiming Dai, Ephraim R. Obot, Brenna M. Marks, Ibrahim Okeil, Edwin A. Sagastume, Moustafa Gabr, F. Christopher Pigge, Frances L. Johnson, Michael K. Schultz
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	MDPI AG 2023-01-01
Serie:	Pharmaceutics
Soggetti:	Lead-212 Bismuth-212 Lead-203 chelators stability theranostics
Accesso online:	https://www.mdpi.com/1999-4923/15/2/414
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