Preclinical Evaluation of a Lead Specific Chelator (PSC) Conjugated to Radiopeptides for ²⁰³Pb and ²¹²Pb-Based Theranostics

²⁰³Pb and ²¹²Pb have emerged as promising theranostic isotopes for image-guided α-particle radionuclide therapy for cancers. Here, we report a cyclen-based Pb specific chelator (PSC) that is conjugated to tyr³-octreotide via a PEG₂ linker (PSC-PEG-T) targe...

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Egile Nagusiak:	Mengshi Li, Nicholas J. Baumhover, Dijie Liu, Brianna S. Cagle, Frédéric Boschetti, Guillaume Paulin, Dongyoul Lee, Zhiming Dai, Ephraim R. Obot, Brenna M. Marks, Ibrahim Okeil, Edwin A. Sagastume, Moustafa Gabr, F. Christopher Pigge, Frances L. Johnson, Michael K. Schultz
Formatua:	Artigo
Hizkuntza:	Inglês
Argitaratua:	MDPI AG 2023-01-01
Saila:	Pharmaceutics
Gaiak:	Lead-212 Bismuth-212 Lead-203 chelators stability theranostics
Sarrera elektronikoa:	https://www.mdpi.com/1999-4923/15/2/414
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