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Identification of new benzofuran derivatives as STING agonists with broad-spectrum antiviral activity

The Stimulator of Interferon Genes (STING) is involved in cytosolic DNA sensing and type I Interferons (IFN-I) induction. Aiming to identify new STING agonists with antiviral activity and given the known biological activity of benzothiazole and benzimidazole derivatives, a series of benzofuran deriv...

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Principais autores: A. Paulis, A. Onali, P.O. Vidalain, V. Lotteau, C. Jaquemin, A. Corona, S. Distinto, G.L. Delogu, E. Tramontano
Format: Artigo
Sprog:Inglês
Udgivet: Elsevier 2024-09-01
Serier:Virus Research
Fag:
STING
Broad-spectrum antiviral
Immune modulation
Benzofurans
Human coronaviruses
Online adgang:http://www.sciencedirect.com/science/article/pii/S0168170224001254
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