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Hybrid Extracellular Vesicles for Efficient Loading and Functional Delivery of mRNA

ABSTRACT Extracellular vesicles (EVs) are an attractive delivery vehicle with biological activity, intrinsic homing, low immunogenicity, and engineerability; however, challenges remain regarding loading and functional delivery of mRNA. Here, we developed a novel approach to load mRNA through low pH‐...

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Principais autores: Xiaoqin Wang, Michael J. Munson, Kristina Friis, Anna Marzeda, Andreia M. Silva, Franziska Kohl, Leif Hultin, Raymond M. Schiffelers, Niek Dekker
Formato: Artigo
Idioma:Inglês
Publicado em: Wiley 2025-12-01
coleção:Journal of Extracellular Vesicles
Assuntos:
cell tolerability
endosomal escape
functional biodistribution
functional delivery
hybrid extracellular vesicle
mRNA loading
Acesso em linha:https://doi.org/10.1002/jev2.70201
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