Hybrid Extracellular Vesicles for Efficient Loading and Functional Delivery of mRNA

ABSTRACT Extracellular vesicles (EVs) are an attractive delivery vehicle with biological activity, intrinsic homing, low immunogenicity, and engineerability; however, challenges remain regarding loading and functional delivery of mRNA. Here, we developed a novel approach to load mRNA through low pH‐...

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Hlavní autoři:	Xiaoqin Wang, Michael J. Munson, Kristina Friis, Anna Marzeda, Andreia M. Silva, Franziska Kohl, Leif Hultin, Raymond M. Schiffelers, Niek Dekker
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	Wiley 2025-12-01
Edice:	Journal of Extracellular Vesicles
Témata:	cell tolerability endosomal escape functional biodistribution functional delivery hybrid extracellular vesicle mRNA loading
On-line přístup:	https://doi.org/10.1002/jev2.70201
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