Synthesis of piperazine-based benzimidazole derivatives as potent urease inhibitors and molecular docking studies

Abstract The development of new bioactive compounds is important for progress in therapeutic research. In the present study, we describe the multistep synthetic approach to develop a library of novel benzimidazole analogs incorporating piperazine rings in order to increase their biological activity....

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主要な著者:	Delaram Shahriarynejad, Navid Dastyafteh, Fouzia Naz, Meysam Talebi, Sajedeh Safapoor, Seyedeh Niloufar Ghafouri, Homa Azizian, Maryam Mohammadi-Khanaposhtani, Bagher Larijani, Mehdi Asadi, Massoud Amanlou, Mohammad Mahdavi, Khalid Mohammed Khan
フォーマット:	Artigo
言語:	Inglês
出版事項:	Nature Portfolio 2025-08-01
シリーズ:	Scientific Reports
主題:	Benzimidazole Piperazine Urease inhibition Docking study
オンライン･アクセス:	https://doi.org/10.1038/s41598-025-14723-4
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