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Analysis of high glucose injury using human induced pluripotent stem cell-derived kidney organoids

Abstract Background Diabetic kidney disease (DKD) is one of the most pervasive complications of diabetes worldwide. However, the pathogenesis of DKD remains poorly understood, due to limitations of the models. The hPSC-derived kidney organoids may offer a new possibility to solve the problem. Method...

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Main Authors: Zuping Qian, Die Yang, Yongli Li, Rong Dong, Jingjing Da, Yong Chen, Yan Zha
Format: Artigo
Language:Inglês
Published: BMC 2026-01-01
Series:BMC Nephrology
Subjects:
Diabetic kidney disease (DKD)
Kidney organoids
Glucolipid metabolism
Injury
Apoptosis
Inflammation
Online Access:https://doi.org/10.1186/s12882-025-04566-6
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