The type VI adenylyl cyclase protects cardiomyocytes from β-adrenergic stress by a PKA/STAT3-dependent pathway

Abstract Background The type VI adenylyl cyclase (AC6) is a main contributor of cAMP production in the heart. The amino acid (aa) sequence of AC6 is highly homologous to that of another major cardiac adenylyl cyclase, AC5, except for its N-terminus (AC6-N, aa 1–86). Activation of AC6, rather than AC...

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Detalhes bibliográficos

Principais autores:	Yu-Shuo Wu, Chien-Chang Chen, Chen-Li Chien, Hsing-Lin Lai, Si-Tse Jiang, Yong-Cyuan Chen, Lin-Ping Lai, Wei-Fan Hsiao, Wen-Pin Chen, Yijuang Chern
Formato:	Artigo
Idioma:	Inglês
Publicado em:	BMC 2017-09-01
coleção:	Journal of Biomedical Science
Assuntos:	Type V adenylyl cyclase AC6 cAMP STAT3 Microdomain
Acesso em linha:	http://link.springer.com/article/10.1186/s12929-017-0367-3
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