Computational insights into pH effects on protein conformation, membrane curvature, and water permeation in the E. coli multidrug efflux transporter MdfA

Abstract Multidrug resistance (MDR) in bacteria poses a major public health challenge, driven largely by efflux transporters such as the Escherichia coli multidrug transporter MdfA. As a proton-coupled antiporter belonging to the Major Facilitator Superfamily (MFS), MdfA harnesses the transmembrane...

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Bibliografiske detaljer

Principais autores:	Prince Manu, Prisca Baah Nketia, Arnold Abakah, Paa Kwesi Anfu, Priscilla Osei-Poku, Alexander Kwarteng
Format:	Artigo
Sprog:	Inglês
Udgivet:	Springer 2026-03-01
Serier:	Discover Chemistry
Fag:	Antibiotic resistance Molecular dynamics simulation PH-dependent conformational dynamics Membrane curvature Water permeation Pore radii
Online adgang:	https://doi.org/10.1007/s44371-026-00607-7
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