Loss of mitochondria long-chain fatty acid oxidation impairs skeletal muscle contractility by disrupting myofibril structure and calcium homeostasis

Objective: Abnormal lipid metabolism in mammalian tissues can be highly deleterious, leading to organ failure. Carnitine Palmitoyltransferase 2 (CPT2) deficiency is an inherited metabolic disorder affecting the liver, heart, and skeletal muscle due to impaired mitochondrial oxidation of long-chain f...

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Үндсэн зохиолчид:	Andrea S. Pereyra, Regina F. Fernandez, Adam Amorese, Jasmine N. Castro, Chien-Te Lin, Espen E. Spangenburg, Jessica M. Ellis
Формат:	Artigo
Хэл сонгох:	Inglês
Хэвлэсэн:	Elsevier 2024-11-01
Цуврал:	Molecular Metabolism
Нөхцлүүд:	Fatty acid oxidation CPT2 Muscle contraction Palmitoyl-carnitine Calcium
Онлайн хандалт:	http://www.sciencedirect.com/science/article/pii/S2212877824001467
Шошгууд:	Шошго нэмэх Шошго байхгүй, Энэхүү баримтыг шошголох эхний хүн болох!