Arg1 from Cryptococcus neoformans lacks PI3 kinase activity and conveys virulence roles via its IP3-4 kinase activity

ABSTRACT Inositol tris/tetrakis phosphate kinases (IP3-4K) in the human fungal priority pathogens, Cryptococcus neoformans (CnArg1) and Candida albicans (CaIpk2), convey numerous virulence functions, yet it is not known whether the IP3-4K catalytic activity or a scaffolding role is responsible. We t...

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Bibliografische Detailangaben

Hauptverfasser:	Desmarini Desmarini, Guizhen Liu, Henning Jessen, Bethany Bowring, Angela Connolly, Ben Crossett, Julianne Teresa Djordjevic
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	American Society for Microbiology 2024-06-01
Schriftenreihe:	mBio
Schlagworte:	Cryptococcus neoformans Candida albicans fungi mycology virulence inositol polyphosphate kinase
Online-Zugang:	https://journals.asm.org/doi/10.1128/mbio.00608-24
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