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Arg1 from Cryptococcus neoformans lacks PI3 kinase activity and conveys virulence roles via its IP3-4 kinase activity

ABSTRACT Inositol tris/tetrakis phosphate kinases (IP3-4K) in the human fungal priority pathogens, Cryptococcus neoformans (CnArg1) and Candida albicans (CaIpk2), convey numerous virulence functions, yet it is not known whether the IP3-4K catalytic activity or a scaffolding role is responsible. We t...

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Kaydedildi:
Asıl Yazarlar: Desmarini Desmarini, Guizhen Liu, Henning Jessen, Bethany Bowring, Angela Connolly, Ben Crossett, Julianne Teresa Djordjevic
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: American Society for Microbiology 2024-06-01
Seri Bilgileri:mBio
Konular:
Cryptococcus neoformans
Candida albicans
fungi
mycology
virulence
inositol polyphosphate kinase
Online Erişim:https://journals.asm.org/doi/10.1128/mbio.00608-24
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