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Lys98 substitution in human AP endonuclease 1 affects the kinetic mechanism of enzyme action in base excision and nucleotide incision repair pathways.

Human apurinic/apyrimidinic endonuclease 1 (APE1) is a key enzyme in the base excision repair (BER) and nucleotide incision repair (NIR) pathways. We recently analyzed the conformational dynamics and kinetic mechanism of wild-type (wt) protein, in a stopped-flow fluorescence study. In this study, we...

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Principais autores: Nadezhda A Timofeyeva, Vladimir V Koval, Alexander A Ishchenko, Murat K Saparbaev, Olga S Fedorova
פורמט: Artigo
שפה:Inglês
יצא לאור: Public Library of Science (PLoS) 2011-01-01
סדרה:PLoS ONE
גישה מקוונת:http://europepmc.org/articles/PMC3164677?pdf=render
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