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H4K79 and H4K91 histone lactylation, newly identified lactylation sites enriched in breast cancer

Abstract Metabolic reprogramming and epigenetic modification are two hallmarks of cancer. Protein lysine lactylation (Kla) is a novel type of glycolysis lactate-triggered posttranslational modification. However, the role of Kla in breast cancer (BC) remains largely unknown. Here, western blot, and i...

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Autori principali: Jiena Liu, Liuying Zhao, Meisi Yan, Shengye Jin, Lingmin Shang, Jianyu Wang, Qin Wang, Shilu Zhao, Zibo Shen, Tong Liu, Hao Wu, Da Pang
Natura: Artigo
Lingua:Inglês
Pubblicazione: BMC 2025-08-01
Serie:Journal of Experimental & Clinical Cancer Research
Soggetti:
Breast cancer
Lactylation
Glycolysis
Post-translational modifications
Epigenetic modification
Accesso online:https://doi.org/10.1186/s13046-025-03512-6
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