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Jaceosidin Attenuates Sepsis-Induced Myocardial Dysfunction by Promoting SIRT2-Mediated Inhibition of Histone H3K18 Lactylation

<b>Background:</b> Sepsis-induced myocardial dysfunction (SIMD) is a life-threatening complication with limited therapeutic options. Jaceosidin (JAC), a natural flavonoid from Folium Artemisiae Argyi, shows potential in cardiovascular diseases, but its role and mechanism in SIMD remain unclear. This...

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Main Authors: Huiming Yu, Minfu Liu, Shuwan Hou, Jiaqin Wu, Qianqian Du, Fan Feng, Sixiang Wang, Chunli Wang, Kang Xu
Format: Artigo
Language:Inglês
Published: MDPI AG 2026-01-01
Series:Pharmaceuticals
Subjects:
Jaceosidin
sepsis-induced myocardial dysfunction
H3K18la
SIRT2
lactylation
Online Access:https://www.mdpi.com/1424-8247/19/1/97
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