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Prrx1 promotes mesangial cell proliferation and kidney fibrosis through YAP in diabetic nephropathy

Mesangial cell proliferation is an early pathological indicator of diabetic nephropathy (DN). Growing evidence highlights the pivotal role of paired-related homeobox 1 (Prrx1), a key regulator of cellular proliferation and tissue differentiation, in various disease pathogenesis. Notably, Prrx1 is hi...

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Principais autores: Liu Xu, Jiasen Shi, Huan Li, Yunfei Liu, Jingyi Wang, Xizhi Li, Dongxue Ren, Sijie Liu, Heng Wang, Yinfei Lu, Jinfang Song, Lei Du, Qian Lu, Xiaoxing Yin
Format: Artigo
Sprog:Inglês
Udgivet: Elsevier 2025-10-01
Serier:Journal of Pharmaceutical Analysis
Fag:
Diabetic nephropathy
Prrx1
Renal fibrosis
Mesangial cell
YAP
Online adgang:http://www.sciencedirect.com/science/article/pii/S2095177925000644
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