A multivariate approach to identify association between peripheral blood DNA methylation and cerebrospinal fluid biomarkers of Alzheimer disease

Abstract DNA methylation has been shown to play a crucial role in many diseases, including Alzheimer’s disease (AD). Although many studies have correlated DNA methylation in blood samples with risk of clinical AD diagnosis, few have examined links with AD neuropathology. Using data from the Alzheime...

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Principais autores:	Bowei Xiao, Yixiao Zeng, Kathleen Oros Klein, Bianca Granato, Mathieu Blanchette, Xiaojian Shao, Celia M. T. Greenwood
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Nature Portfolio 2025-11-01
coleção:	Scientific Reports
Assuntos:	Alzheimer disease DNA methylation Cerebrospinal fluid biomarkers multivariate analysis penalized models dimension reduction
Acesso em linha:	https://doi.org/10.1038/s41598-025-22004-3
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