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A multivariate approach to identify association between peripheral blood DNA methylation and cerebrospinal fluid biomarkers of Alzheimer disease

Abstract DNA methylation has been shown to play a crucial role in many diseases, including Alzheimer’s disease (AD). Although many studies have correlated DNA methylation in blood samples with risk of clinical AD diagnosis, few have examined links with AD neuropathology. Using data from the Alzheime...

Ausführliche Beschreibung

Gespeichert in:
Hauptverfasser: Bowei Xiao, Yixiao Zeng, Kathleen Oros Klein, Bianca Granato, Mathieu Blanchette, Xiaojian Shao, Celia M. T. Greenwood
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Portfolio 2025-11-01
Schriftenreihe:Scientific Reports
Schlagworte:
Alzheimer disease
DNA methylation
Cerebrospinal fluid biomarkers
multivariate analysis
penalized models
dimension reduction
Online-Zugang:https://doi.org/10.1038/s41598-025-22004-3
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