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Nanoformulation of Talazoparib Delays Tumor Progression and Ascites Formation in a Late Stage Cancer Model

Talazoparib, a potent PARP inhibitor, induces synthetic lethality in BRCA-deficient cancers making it an attractive candidate for ovarian cancer treatment. However, its potency lends itself to side effects associated more closely with traditional chemotherapeutics than other clinically approved PARP...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Paige Baldwin, Anders W. Ohman, Jamie E. Medina, Eric T. McCarthy, Daniela M. Dinulescu, Srinivas Sridhar
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Frontiers Media S.A. 2019-05-01
Cyfres:Frontiers in Oncology
Pynciau:
Mynediad Ar-lein:https://www.frontiersin.org/article/10.3389/fonc.2019.00353/full
Tagiau: Ychwanegu Tag
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