PEGylated talazoparib enhances therapeutic window of its combination with temozolomide in Ewing sarcoma

Summary: Current therapy is ineffective for relapsed and metastatic Ewing sarcoma (EwS) owing to development of drug resistance. Macromolecular prodrugs potentially lead to lower drug exposure in normal tissues and reduced toxicity. We evaluated the efficacy of PEGylated talazoparib (PEG∼TLZ), a PAR...

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Үндсэн зохиолчид:	Vanessa Del Pozo, Andrew J. Robles, Shaun D. Fontaine, Qianqian Liu, Joel E. Michalek, Peter J. Houghton, Raushan T. Kurmasheva
Формат:	Artigo
Хэл сонгох:	Inglês
Хэвлэсэн:	Elsevier 2022-02-01
Цуврал:	iScience
Нөхцлүүд:	Oncology Pharmacology Molecular medicine
Онлайн хандалт:	http://www.sciencedirect.com/science/article/pii/S2589004221016953
Шошгууд:	Шошго нэмэх Шошго байхгүй, Энэхүү баримтыг шошголох эхний хүн болох!