Nicotine-mediated effects in neuronal and mouse models of synucleinopathy

IntroductionAlpha-synuclein (α-Syn) aggregation, transmission, and contribution to neurotoxicity represent central mechanisms underlying Parkinson’s disease. The plant alkaloid “nicotine” was reported to attenuate α-Syn aggregation in different models, but its precise mode of action remains unclear....

पूर्ण विवरण

में बचाया:
ग्रंथसूची विवरण
मुख्य लेखकों: Mohamed Bilal Fares, Omar Alijevic, Stephanie Johne, Cassia Overk, Makoto Hashimoto, Athanasios Kondylis, Anthony Adame, Remi Dulize, Dariusz Peric, Catherine Nury, James Battey, Emmanuel Guedj, Nicolas Sierro, Damian Mc Hugh, Edward Rockenstein, Changyoun Kim, Robert A. Rissman, Julia Hoeng, Manuel C. Peitsch, Eliezer Masliah, Carole Mathis
स्वरूप: Artigo
भाषा:Inglês
प्रकाशित: Frontiers Media S.A. 2023-08-01
श्रृंखला:Frontiers in Neuroscience
विषय:
synucleinopathy
induced pluripotent stem cell (iPSC)
transgenic mice
nicotine
nicotinic acetylcholine receptors (nAChR)
neuroprotection
ऑनलाइन पहुंच:https://www.frontiersin.org/articles/10.3389/fnins.2023.1239009/full
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