Thiamine transporter 2 and Janus kinase 2 inhibitor, fedratinib suppresses thermogenic activation of human neck area-derived adipocytes

IntroductionBrown adipocytes consume higher amounts of metabolic substrates and regulators, including thiamine, during adrenergic stimulation, supporting heat generation. Our previous findings showed that fedratinib, a potent inhibitor of thiamine transporter (ThTr) 2 and Janus kinase 2 (JAK2), redu...

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Bibliografische Detailangaben

Hauptverfasser:	Gyath Karadsheh, Emília Kovács, Rahaf Alrifai, Mizuki Seo, Ferenc Győry, Renáta Csatári-Kovács, Éva Csősz, Szilárd Póliska, László Fésüs, Rini Arianti, Endre Kristóf
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	Frontiers Media S.A. 2026-02-01
Schriftenreihe:	Frontiers in Endocrinology
Schlagworte:	fedratinib human adipocytes JAK SLC19A3 thermogenesis thiamine
Online-Zugang:	https://www.frontiersin.org/articles/10.3389/fendo.2026.1694542/full
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