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IGH rearrangements in Down syndrome acute lymphoblastic leukemia

Background: The IGH locus is susceptible to translocations or insertions that contribute to B-cell precursor acute lymphoblastic leukemia (ALL) by ectopic or enhanced expression of a gene relocated to the IGH enhancer. The frequency of IGH rearrangements is relatively high in Down syndrome (DS) ALL....

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Gardado en:
Principais autores: Naomi Michels, Jade Admiraal, Aurélie Boeree, Edwin Sonneveld, Anthony V. Moorman, Gabriele Escherich, Rosemary Sutton, H. Berna Beverloo, Rob Pieters, C. Michel Zwaan, Monique L. den Boer, Judith M. Boer
Formato: Artigo
Idioma:Inglês
Publicado: Elsevier 2025-06-01
Series:EJC Paediatric Oncology
Assuntos:
Fluorescence in situ hybridization
Pediatric
Down syndrome
RNA sequencing
Acceso en liña:http://www.sciencedirect.com/science/article/pii/S2772610X25000108
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