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PM2.5 leads to adverse pregnancy outcomes by inducing trophoblast oxidative stress and mitochondrial apoptosis via KLF9/CYP1A1 transcriptional axis

Epidemiological studies have demonstrated that fine particulate matter (PM2.5) is associated with adverse obstetric and postnatal metabolic health outcomes, but the mechanism remains unclear. This study aimed to investigate the toxicological pathways by which PM2.5 damaged placental trophoblasts in...

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Principais autores: Shuxian Li, Lingbing Li, Changqing Zhang, Huaxuan Fu, Shuping Yu, Meijuan Zhou, Junjun Guo, Zhenya Fang, Anna Li, Man Zhao, Meihua Zhang, Xietong Wang
Format: Artigo
Sprog:Inglês
Udgivet: eLife Sciences Publications Ltd 2023-09-01
Serier:eLife
Fag:
fine particulate matter
KLF9
trophoblast
oxidative stress
mitochondrial apoptosis
CYP1A1
Online adgang:https://elifesciences.org/articles/85944
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