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SS-31 alleviated nociceptive responses and restored mitochondrial function in a headache mouse model via Sirt3/Pgc-1α positive feedback loop

Abstract Migraine is the second highest cause of disability worldwide, bringing a huge socioeconomic burden. Improving mitochondrial function has promise as an effective treatment strategy for migraine. Szeto-Schiller peptide (SS-31) is a new mitochondria-targeted tetrapeptide molecule that has been...

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Principais autores: Zhengming Shan, Yajuan Wang, Tao Qiu, Yanjie Zhou, Yu Zhang, Luyu Hu, Lili Zhang, Jingjing Liang, Man Ding, Shanghua Fan, Zheman Xiao
Format: Artigo
Sprog:Inglês
Udgivet: BMC 2023-06-01
Serier:The Journal of Headache and Pain
Fag:
SS-31
Migraine
Mitochondrial dysfunction
Mitochondrial homeostasis
Sirt3
Pgc-1α
Online adgang:https://doi.org/10.1186/s10194-023-01600-6
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