The Crucial Role of Demannosylating Asparagine-Linked Glycans in ERADicating Misfolded Glycoproteins in the Endoplasmic Reticulum

Most membrane and secreted proteins are glycosylated on certain asparagine (N) residues in the endoplasmic reticulum (ER), which is crucial for their correct folding and function. Protein folding is a fundamentally inefficient and error-prone process that can be easily interfered by genetic mutation...

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Principais autores:	Jianjun Zhang, Jiarui Wu, Linchuan Liu, Jianming Li
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Frontiers Media S.A. 2021-01-01
coleção:	Frontiers in Plant Science
Assuntos:	endoplasmic reticulum asparagine-linked glycan endoplasmic reticulum-associated degradation mannosidase protein disulfide isomerases
Acesso em linha:	https://www.frontiersin.org/articles/10.3389/fpls.2020.625033/full
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