CleanCap M6 inhibits decapping of exogenously delivered IVT mRNA

Co-transcriptional capping allows exogenous mRNAs to yield robust protein expression. Identifying additional mRNA modifications that further boost protein output will be crucial for developing more efficacious mRNA therapies. Using in vitro approaches, we found that the co-transcriptional cap analog...

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Bibliografski detalji

Glavni autori:	Zachary F. Mandell, Andrew Ujita, Jordana Henderson, Anthony Truong, Coleen Vo, Farinaz Rezvani, Nona Abolhassani, Alexandre Lebedev, Chunping Xu, Inna Koukhareva, Stephanie Ramos, Kate Broderick, Benjamin Hudson, Jeff Coller
Format:	Artigo
Jezik:	Inglês
Izdano:	Elsevier 2025-03-01
Serija:	Molecular Therapy: Nucleic Acids
Teme:	MT: Delivery Strategies mRNA mRNA medicines mRNA therapeutics mRNA durability mRNA stability
Online pristup:	http://www.sciencedirect.com/science/article/pii/S2162253125000101
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