EHD2 overexpression promotes tumorigenesis and metastasis in triple-negative breast cancer by regulating store-operated calcium entry

With nearly all cancer deaths a result of metastasis, elucidating novel pro-metastatic cellular adaptations could provide new therapeutic targets. Here, we show that overexpression of the EPS15-Homology Domain-containing 2 (EHD2) protein in a large subset of breast cancers (BCs), especially the trip...

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Detalhes bibliográficos

Principais autores:	Haitao Luan, Timothy A Bielecki, Bhopal C Mohapatra, Namista Islam, Insha Mushtaq, Aaqib M Bhat, Sameer Mirza, Sukanya Chakraborty, Mohsin Raza, Matthew D Storck, Michael S Toss, Jane L Meza, Wallace B Thoreson, Donald W Coulter, Emad A Rakha, Vimla Band, Hamid Band
Formato:	Artigo
Idioma:	Inglês
Publicado em:	eLife Sciences Publications Ltd 2023-01-01
Colecção:	eLife
Assuntos:	triple negative breast cancer EHD2 SOCE caveolae caveolin-1 caveolin-2
Acesso em linha:	https://elifesciences.org/articles/81288
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