EHD2 overexpression promotes tumorigenesis and metastasis in triple-negative breast cancer by regulating store-operated calcium entry

With nearly all cancer deaths a result of metastasis, elucidating novel pro-metastatic cellular adaptations could provide new therapeutic targets. Here, we show that overexpression of the EPS15-Homology Domain-containing 2 (EHD2) protein in a large subset of breast cancers (BCs), especially the trip...

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Автори:	Haitao Luan, Timothy A Bielecki, Bhopal C Mohapatra, Namista Islam, Insha Mushtaq, Aaqib M Bhat, Sameer Mirza, Sukanya Chakraborty, Mohsin Raza, Matthew D Storck, Michael S Toss, Jane L Meza, Wallace B Thoreson, Donald W Coulter, Emad A Rakha, Vimla Band, Hamid Band
Формат:	Artigo
Мова:	Inglês
Опубліковано:	eLife Sciences Publications Ltd 2023-01-01
Серія:	eLife
Предмети:	triple negative breast cancer EHD2 SOCE caveolae caveolin-1 caveolin-2
Онлайн доступ:	https://elifesciences.org/articles/81288
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EHD2 overexpression promotes tumorigenesis and metastasis in triple-negative breast cancer by regulating store-operated calcium entry

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