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The crystal structure of the toxin EspC from enteropathogenic Escherichia coli reveals the mechanism that governs host cell entry and cytotoxicity

Enteropathogenic E. coli (EPEC) is a significant cause of diarrhea, leading to high infant mortality rates. A key toxin produced by EPEC is the EspC autotransporter, which is regulated alongside genes from the locus of enterocyte effacement (LEE), which collectively result in the characteristic atta...

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Principais autores: Akila U. Pilapitiya, Lilian Hor, Jing Pan, Lakshmi C. Wijeyewickrema, Robert N. Pike, Denisse L. Leyton, Jason J Paxman, Begoña Heras
Format: Artigo
Sprog:Inglês
Udgivet: Taylor & Francis Group 2025-12-01
Serier:Gut Microbes
Fag:
Enteropathogenic E. coli
autotransporter protein
serine protease
toxins
bacterial infections
secretion system
Online adgang:https://www.tandfonline.com/doi/10.1080/19490976.2025.2483777
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