The crystal structure of the toxin EspC from enteropathogenic Escherichia coli reveals the mechanism that governs host cell entry and cytotoxicity

Enteropathogenic E. coli (EPEC) is a significant cause of diarrhea, leading to high infant mortality rates. A key toxin produced by EPEC is the EspC autotransporter, which is regulated alongside genes from the locus of enterocyte effacement (LEE), which collectively result in the characteristic atta...

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Hlavní autoři:	Akila U. Pilapitiya, Lilian Hor, Jing Pan, Lakshmi C. Wijeyewickrema, Robert N. Pike, Denisse L. Leyton, Jason J Paxman, Begoña Heras
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	Taylor & Francis Group 2025-12-01
Edice:	Gut Microbes
Témata:	Enteropathogenic E. coli autotransporter protein serine protease toxins bacterial infections secretion system
On-line přístup:	https://www.tandfonline.com/doi/10.1080/19490976.2025.2483777
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