Disruption of Proteostasis by Natural Products and Synthetic Compounds That Induce Pervasive Unfolding of Proteins: Therapeutic Implications

Exposure of many cancer cells, including multiple myeloma cells, to cytotoxic concentrations of natural products celastrol and withaferin A or synthetic compounds of the IHSF series resulted in denaturation of a luciferase reporter protein. Proteomic analysis of detergent-insoluble extract fractions...

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Ngā kaituhi matua:	Nuria Vilaboa, Juan Antonio Lopez, Marco de Mesa, Clara Escudero-Duch, Natalie Winfield, Melanie Bayford, Richard Voellmy
Hōputu:	Artigo
Reo:	Inglês
I whakaputaina:	MDPI AG 2023-04-01
Rangatū:	Pharmaceuticals
Ngā marau:	proteostasis inhibition proteostasis disruption protein unfolding protein aggregation IHSF celastrol
Urunga tuihono:	https://www.mdpi.com/1424-8247/16/4/616
Ngā Tūtohu:	Tāpirihia he Tūtohu Kāore He Tūtohu, Me noho koe te mea tuatahi ki te tūtohu i tēnei pūkete!