Integrated screening for small molecules interfering with PKM2: a drug repurposing strategy against glioblastoma
Abstract Background Glioblastoma (GBM), the most aggressive adult brain tumor, remains a significant clinical challenge. Pyruvate kinase M2 (PKM2), by shifting between its tetrameric (metabolic) and dimeric (oncogenic) forms, drives GBM metabolism and tumorigenesis, regulating the Warburg effect. Th...
Збережено в:
| Автори: | , , , , , , , , , , , , , |
|---|---|
| Формат: | Artigo |
| Мова: | Inglês |
| Опубліковано: |
BMC
2025-12-01
|
| Серія: | Journal of Translational Medicine |
| Предмети: | |
| Онлайн доступ: | https://doi.org/10.1186/s12967-025-07444-9 |
| Теги: |
Немає тегів, Будьте першим, хто поставить тег для цього запису!
|