Integrated screening for small molecules interfering with PKM2: a drug repurposing strategy against glioblastoma

Abstract Background Glioblastoma (GBM), the most aggressive adult brain tumor, remains a significant clinical challenge. Pyruvate kinase M2 (PKM2), by shifting between its tetrameric (metabolic) and dimeric (oncogenic) forms, drives GBM metabolism and tumorigenesis, regulating the Warburg effect. Th...

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Bibliografski detalji

Glavni autori:	Susan Costantini, Isabella Romeo, Giulia Fanelli, Maria Serena Roca, Gianmarco Gualtieri, Palmina Bagnara, Andrea Polo, Elena Di Gennaro, Francesco Ortuso, Stefano Alcaro, Alfredo Budillon, Gennaro Ciliberto, Marco G. Paggi, Claudia Abbruzzese
Format:	Artigo
Jezik:	Inglês
Izdano:	BMC 2025-12-01
Serija:	Journal of Translational Medicine
Teme:	Glioblastoma PKM2 Drug screening Drug repurposing
Online pristup:	https://doi.org/10.1186/s12967-025-07444-9
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