TDP-43 mutants with different aggregation properties exhibit distinct toxicity, axonal transport, and secretion for disease progression in a mouse ALS/FTLD model

TDP-43 accumulates and forms inclusions in neurons in amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration (FTLD) and is assumed to cause neurodegenerative processes. The morphologies and cellular and areal distributions of accumulated TDP-43 inclusions are pathologically divers...

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Detalhes bibliográficos

Principais autores:	Hideki Mori, Tokiharu Sato, Shintaro Tsuboguchi, Masahiko Takahashi, Yuka Nakamura, Kana Hoshina, Taisuke Kato, Masahiro Fujii, Osamu Onodera, Masaki Ueno
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Elsevier 2025-08-01
Colecção:	Neurobiology of Disease
Assuntos:	Axon initial segment (AIS) Callosal Corticospinal Layer V Sensorimotor cortex Spreading
Acesso em linha:	http://www.sciencedirect.com/science/article/pii/S0969996125002049
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