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Catalytic activity of TiO2 nanoparticles in cyclization reactions for pyrazolone formation: DNA binding analysis via spectroscopy, X-ray crystallography, and molecular docking

This method of sustainable synthesis utilizes a range of aromatic/heterocyclic aldehydes, phenylhydrazine, and ethyl acetoacetates. The TiO2 nanoparticle catalyst facilitates cyclization reactions, yielding pyrazolone derivatives with exceptional efficiency (95–97 %) under reflux conditions at 80 °C...

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Principais autores: Mehtab Parveen, Uzma, Mohammad Azam, Mohammad Azeem, Afroz Aslam, Masrat Bashir, Mahboob Alam
Format: Artigo
Sprog:Inglês
Udgivet: Springer 2024-07-01
Serier:Journal of Saudi Chemical Society
Fag:
TiO2NPs
Pyrazolone
Knoevenagel condensation
X-ray crystal structure
DNA-binding activity
Online adgang:http://www.sciencedirect.com/science/article/pii/S1319610324000760
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