Very early remission and increased apoptosis with the use of Pentoxifylline in children with acute lymphoblastic leukemia

IntroductionDespite the improvement in survival in acute lymphoblastic leukemia (ALL), there are still cases with evasion of chemotherapy-induced apoptosis. The IKK/NF-κB signaling pathway contributes to antiapoptotic gene expression. Pentoxifylline (PTX) inhibits IkB phosphorylation, blocking NF-κB...

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Principais autores:	Violeta Salceda-Rivera, Pablo C. Ortiz-Lazareno, Georgina Hernández-Flores, Jorge R. Vazquez-Urrutia, Jesus Meza-Arroyo, Monzerrat Pardo-Zepeda, Hugo Romo-Rubio, Cesar Barba-Barba, Fernando Sánchez-Zubieta, Carlos Alfredo Barrón-Gallardo, Oscar Gonzalez-Ramella, Alejandro Bravo-Cuellar
Formato:	Artigo
Idioma:	Inglês
Publicado:	Frontiers Media S.A. 2024-10-01
Series:	Frontiers in Oncology
Assuntos:	MRD ALL clinical trials apoptosis Pentoxifylline early remission
Acceso en liña:	https://www.frontiersin.org/articles/10.3389/fonc.2024.1401262/full
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