Activation of AMPK/mTOR-Driven Autophagy and Suppression of the HMGB1/TLR4 Pathway with Pentoxifylline Attenuates Doxorubicin-Induced Hepatic Injury in Rats

Despite being an effective chemotherapeutic agent, the clinical use of doxorubicin (DOX) is limited by several organ toxicities including hepatic injury. Pentoxifylline (PTX) is a methylxanthine derivative with marked anti-inflammatory and anti-apoptotic features. It is unknown, however, whether PTX...

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Autori principali:	Hany H. Arab, Ahmed H. Eid, Shuruq E. Alsufyani, Ahmed M. Ashour, Alwaleed M. Alnefaie, Nasser M. Alsharif, Abdullah M. Alshehri, Abdulmajeed A. Almalawi, Abdulmajeed A. Alsowat, Hayat A. Abd El Aal, Eman S. G. Hassan, Wessam H. Elesawy, Alzahraa A. Elhemiely
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	MDPI AG 2024-05-01
Serie:	Pharmaceuticals
Soggetti:	pentoxifylline doxorubicin hepatotoxicity autophagy AMPK HMGB1
Accesso online:	https://www.mdpi.com/1424-8247/17/6/681
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