Kallistatin leads to cognition impairment via downregulating glutamine synthetase

In many neurodegenerative disorders, such as Alzheimer's disease (AD), glutamate-mediated neuronal excitotoxicity is considered the basis for cognitive impairment. The mRNA and protein expression of SERPINA4(Kallistatin) are higher in patients with AD. However, whether Kallistatin plays a regulatory...

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Bibliografiske detaljer

Principais autores:	Yanlan Long, Zhen Zhao, Wanting Xie, Jinhui Shi, Fengyu Yang, Dan Zhu, Ping Jiang, Qilong Tang, Zhou Ti, Bin Jiang, Xia Yang, Guoquan Gao, Weiwei Qi
Format:	Artigo
Sprog:	Inglês
Udgivet:	Elsevier 2024-04-01
Serier:	Pharmacological Research
Fag:	Cognition impairment Kallistatin Glutamine synthetase Proteasome-mediated degradation
Online adgang:	http://www.sciencedirect.com/science/article/pii/S1043661824000896
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