Kallistatin leads to cognition impairment via downregulating glutamine synthetase

In many neurodegenerative disorders, such as Alzheimer's disease (AD), glutamate-mediated neuronal excitotoxicity is considered the basis for cognitive impairment. The mRNA and protein expression of SERPINA4(Kallistatin) are higher in patients with AD. However, whether Kallistatin plays a regulatory...

Descrición completa

Detalles Bibliográficos

Principais autores:	Yanlan Long, Zhen Zhao, Wanting Xie, Jinhui Shi, Fengyu Yang, Dan Zhu, Ping Jiang, Qilong Tang, Zhou Ti, Bin Jiang, Xia Yang, Guoquan Gao, Weiwei Qi
Formato:	Artigo
Idioma:	Inglês
Publicado:	Elsevier 2024-04-01
Series:	Pharmacological Research
Assuntos:	Cognition impairment Kallistatin Glutamine synthetase Proteasome-mediated degradation
Acceso en liña:	http://www.sciencedirect.com/science/article/pii/S1043661824000896
Tags:	Engadir etiqueta Sen Etiquetas, Sexa o primeiro en etiquetar este rexistro!