CHB‐Induced Immune Zonation Chaos Elicited LXRα‐mediated Lipid Metabolism Disorders in Kupffer Cells to Induce Cancer Stem Cell Formation

Abstract Hepatic intercellular communication is the driving force for the progression of chronic Hepatitis B virus (CHB)‐associated hepatopathologies, with the dynamic molecular mechanisms largely unknown. Combining scRNA‐seq and spatial transcriptomic analysis, the kinetic landscape of the liver mi...

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Bibliografische Detailangaben

Hauptverfasser:	Jingqi Shi, Qingyu Li, Jian Li, Jian Bai, Ji Xi, Qi He, Jianglin Zhou, Xuejun Wang, Xiang Song, Xiaoju Li, Xiangpei Yue, Xiaochang Zhang, Zhen Sun, Jiangbo Li, Wen Yang, Yuke Cui, Wenjie Shu, Liang Guo, Shengqi Wang
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	Wiley 2026-02-01
Schriftenreihe:	Advanced Science
Schlagworte:	chronic HBV inflammation‐to‐carcinoma transition Kupffer cell lipid metabolism disorder LXRα
Online-Zugang:	https://doi.org/10.1002/advs.202510275
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