CHB‐Induced Immune Zonation Chaos Elicited LXRα‐mediated Lipid Metabolism Disorders in Kupffer Cells to Induce Cancer Stem Cell Formation

Abstract Hepatic intercellular communication is the driving force for the progression of chronic Hepatitis B virus (CHB)‐associated hepatopathologies, with the dynamic molecular mechanisms largely unknown. Combining scRNA‐seq and spatial transcriptomic analysis, the kinetic landscape of the liver mi...

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Hlavní autoři:	Jingqi Shi, Qingyu Li, Jian Li, Jian Bai, Ji Xi, Qi He, Jianglin Zhou, Xuejun Wang, Xiang Song, Xiaoju Li, Xiangpei Yue, Xiaochang Zhang, Zhen Sun, Jiangbo Li, Wen Yang, Yuke Cui, Wenjie Shu, Liang Guo, Shengqi Wang
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	Wiley 2026-02-01
Edice:	Advanced Science
Témata:	chronic HBV inflammation‐to‐carcinoma transition Kupffer cell lipid metabolism disorder LXRα
On-line přístup:	https://doi.org/10.1002/advs.202510275
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