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Age-dependent brain responses to mechanical stress determine resilience in a chronic lymphatic drainage impairment model

The outflow of ‘dirty’ brain fluids from the glymphatic system drains via the meningeal lymphatic vessels to the lymph nodes in the neck, primarily the deep cervical lymph nodes (dcLN). However, it is unclear whether dcLN drainage is essential for normal cerebral homeostasis. Using dynamic contrast-...

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Detalhes bibliográficos
Principais autores: Zachary Gursky, Zohaib Nisar Khan, Sunil Koundal, Ankita Bhardwaj, Joaquin Caceres Melgarejo, Kaiming Xu, Xinan Chen, Hung-Mo Lin, Xianfeng Gu, Hedok Lee, Jonathan Kipnis, Yoav Dori, Allen Tannenbaum, Laura Santambrogio, Helene Benveniste
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2025-09-01
coleção:The Journal of Clinical Investigation
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Acesso em linha:https://doi.org/10.1172/JCI182555
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