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Oncostatin M-driven macrophage-fibroblast circuits as a drug target in autoimmune arthritis

Abstract Background Recent single-cell RNA sequencing (scRNA-seq) analysis revealed the functional heterogeneity and pathogenic cell subsets in immune cells, synovial fibroblasts and bone cells in rheumatoid arthritis (RA). JAK inhibitors which ameliorate joint inflammation and bone destruction in R...

Ausführliche Beschreibung

Gespeichert in:
Hauptverfasser: Nam Cong-Nhat Huynh, Rui Ling, Masatsugu Komagamine, Tianshu Shi, Masayuki Tsukasaki, Kotaro Matsuda, Kazuo Okamoto, Tatsuo Asano, Ryunosuke Muro, Warunee Pluemsakunthai, George Kollias, Yuko Kaneko, Tsutomu Takeuchi, Sakae Tanaka, Noriko Komatsu, Hiroshi Takayanagi
Format: Artigo
Sprache:Inglês
Veröffentlicht: BMC 2024-07-01
Schriftenreihe:Inflammation and Regeneration
Schlagworte:
Rheumatoid arthritis
JAK inhibitor
Macrophage
Synovial fibroblast
Drug target
Online-Zugang:https://doi.org/10.1186/s41232-024-00347-0
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