Oncostatin M-driven macrophage-fibroblast circuits as a drug target in autoimmune arthritis

Abstract Background Recent single-cell RNA sequencing (scRNA-seq) analysis revealed the functional heterogeneity and pathogenic cell subsets in immune cells, synovial fibroblasts and bone cells in rheumatoid arthritis (RA). JAK inhibitors which ameliorate joint inflammation and bone destruction in R...

Popoln opis

Bibliografske podrobnosti

Principais autores:	Nam Cong-Nhat Huynh, Rui Ling, Masatsugu Komagamine, Tianshu Shi, Masayuki Tsukasaki, Kotaro Matsuda, Kazuo Okamoto, Tatsuo Asano, Ryunosuke Muro, Warunee Pluemsakunthai, George Kollias, Yuko Kaneko, Tsutomu Takeuchi, Sakae Tanaka, Noriko Komatsu, Hiroshi Takayanagi
Format:	Artigo
Jezik:	Inglês
Izdano:	BMC 2024-07-01
Serija:	Inflammation and Regeneration
Teme:	Rheumatoid arthritis JAK inhibitor Macrophage Synovial fibroblast Drug target
Online dostop:	https://doi.org/10.1186/s41232-024-00347-0
Oznake:	Označite Brez oznak, prvi označite!