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Identfication of Potent LXRβ-Selective Agonists without LXRα Activation by In Silico Approaches

Activating Liver X receptors (LXRs) represents a promising therapeutic option for dyslipidemia. However, activating LXRα may cause undesired lipogenic effects. Discovery of highly LXRβ-selective agonists without LXRα activation were indispensable for dyslipidemia. In this study, in...

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Principais autores: Meimei Chen, Fafu Yang, Jie Kang, Huijuan Gan, Xuemei Yang, Xinmei Lai, Yuxing Gao
Format: Artigo
Sprog:Inglês
Udgivet: MDPI AG 2018-06-01
Serier:Molecules
Fag:
LXRβ-selective agonists
QSAR modeling
molecular docking
Kohonen
Online adgang:http://www.mdpi.com/1420-3049/23/6/1349
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