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Single mutation tunes IRF4 function and mediates B cell character to ameliorate murine lupus

Summary: Systemic lupus erythematosus (SLE) is a systemic autoimmune disease characterized by abundant autoantibodies. B cells play a critical role in initiation and progress of SLE, showing immunotolerance loss, hyperactivity, and abnormal activation or maturation. Interferon regulatory factor 4 (I...

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Principais autores: Ze Xiu Xiao, Rongzhen Liang, Xiaojiang Hu, Changyuan Huang, Jia Nie, Chichu Xie, Julie Wang, Qiannan Fang, Xiaoli Fan, Nancy Olsen, Li Zhou, Bin Li, Song Guo Zheng
Format: Artigo
Sprog:Inglês
Udgivet: Elsevier 2025-11-01
Serier:iScience
Fag:
Immune system
Immunology
Online adgang:http://www.sciencedirect.com/science/article/pii/S2589004225021455
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