Genome-wide risk prediction of common diseases across ancestries in one million people

Summary: Polygenic risk scores (PRS) measure genetic disease susceptibility by combining risk effects across the genome. For coronary artery disease (CAD), type 2 diabetes (T2D), and breast and prostate cancer, we performed cross-ancestry evaluation of genome-wide PRSs in six biobanks in Europe, the...

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Autores principales:	Nina Mars, Sini Kerminen, Yen-Chen A. Feng, Masahiro Kanai, Kristi Läll, Laurent F. Thomas, Anne Heidi Skogholt, Pietro della Briotta Parolo, Benjamin M. Neale, Jordan W. Smoller, Maiken E. Gabrielsen, Kristian Hveem, Reedik Mägi, Koichi Matsuda, Yukinori Okada, Matti Pirinen, Aarno Palotie, Andrea Ganna, Alicia R. Martin, Samuli Ripatti
Formato:	Artigo
Lenguaje:	Inglês
Publicado:	Elsevier 2022-04-01
Colección:	Cell Genomics
Materias:	polygenic risk score health disparities global health ancestry precision medicine risk prediction
Acceso en línea:	http://www.sciencedirect.com/science/article/pii/S2666979X22000428
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