Krüppel-like Factor-4-Mediated Macrophage Polarization and Phenotypic Transitions Drive Intestinal Fibrosis in THP-1 Monocyte Models In Vitro

<i>Background and Objectives</i>: Despite the fact that biologic drugs have transformed inflammatory bowel disease (IBD) treatment, addressing fibrosis-related strictures remains a research gap. This study explored the roles of cytokines, macrophages, and Krüppel-like factors (KLFs), specifically KL...

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Autors principals:	Takuya Kanno, Takahito Katano, Takaya Shimura, Mamoru Tanaka, Hirotada Nishie, Shigeki Fukusada, Keiji Ozeki, Isamu Ogawa, Takahiro Iwao, Tamihide Matsunaga, Hiromi Kataoka
Format:	Artigo
Idioma:	Inglês
Publicat:	MDPI AG 2024-04-01
Col·lecció:	Medicina
Matèries:	human-induced pluripotent stem cell inflammatory bowel disease interleukin-1 interleukin-10 interleukin-36 myofibroblast
Accés en línia:	https://www.mdpi.com/1648-9144/60/5/713
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