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Krüppel-like Factor-4-Mediated Macrophage Polarization and Phenotypic Transitions Drive Intestinal Fibrosis in THP-1 Monocyte Models In Vitro

<i>Background and Objectives</i>: Despite the fact that biologic drugs have transformed inflammatory bowel disease (IBD) treatment, addressing fibrosis-related strictures remains a research gap. This study explored the roles of cytokines, macrophages, and Krüppel-like factors (KLFs), specifically KL...

Ausführliche Beschreibung

Gespeichert in:
Hauptverfasser: Takuya Kanno, Takahito Katano, Takaya Shimura, Mamoru Tanaka, Hirotada Nishie, Shigeki Fukusada, Keiji Ozeki, Isamu Ogawa, Takahiro Iwao, Tamihide Matsunaga, Hiromi Kataoka
Format: Artigo
Sprache:Inglês
Veröffentlicht: MDPI AG 2024-04-01
Schriftenreihe:Medicina
Schlagworte:
human-induced pluripotent stem cell
inflammatory bowel disease
interleukin-1
interleukin-10
interleukin-36
myofibroblast
Online-Zugang:https://www.mdpi.com/1648-9144/60/5/713
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